Cortical injury in multiple sclerosis; the role of the immune system.
Caroline A Walker (caroline.aldridge@yale.edu), Anita J Huttner (anita.hutner@yale.edu). Kevin C OConnor (kevin.oconnor@yale.edu).
The easily identifiable, ubiquitous demyelination and neuronal damage that occurs within the cerebral white matter of patients with multiple sclerosis (MS) has been the subject of extensive study......

Gray matter imaging in multiple sclerosis: what have we learned?
At the early onset of the 20th century, several studies already reported that the gray matter was implicated in the histopathology of multiple sclerosis (MS). However, as white matter pathology long received predominant attention in this disease.........

HIV-Associated Hodgkin’s Lymphoma: Prognosis and Therapy in the Era of cART.
1Dana-Farber Cancer Institute, Boston, MA 02215, USA. 2Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
Patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) are at increased risk for developing Hodgkin’s lymphoma (HL), a risk that has not decreased despite the success of combination antiretroviral therapy (cART) in the modern era. HIV-associated______

Excess mortality related to seasonal influenza and extreme temperatures in Denmark, 1994-2010.
In temperate zones, all-cause mortality exhibits a marked seasonality, and one of the main causes of winter excess mortality is influenza. There is a tradition of using statistical models based on mortality from respiratory illnesses.....

Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis.
Community-acquired pneumonia (CAP) is considered the most important cause of death from infectious disease in developed countries. Severity assessment scores partially address the difficulties in identifying high-risk patients. A lack of specific and valid.......

Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: An observational study.
Leptospirosis has a varied clinical presentation with complications like myocarditis and acute renal failure. There are many predictors of severity and mortality including clinical......

The Role of Autologous StemCell Transplantation in the Treatment of Diffuse Large B-Cell Lymphom.
Diffuse large B-cell non-Hodgkin’s lymphoma (DLBCL) accounting for approximately 30% of new lymphoma diagnoses in adult patients. Complete remissions (CRs) can be achieved in 45% to 55% of patients and cure in approximately 30–35% with anthracycline-containing combination........

Engineered T Cells for the Adoptive Therapy of B-Cell Chronic Lymphocytic Leukaemia.
B-cell chronic lymphocytic leukaemia (B-CLL) remains an incurable disease due to the high risk of relapse, even after complete remission, raising the need to control and eliminate residual tumor cells in long term. Adoptive T cell therapy with......